Although multiple MRI techniques have been developed to detect and monitor myelin loss and repair, their sensitivity to myelin is often impaired by the underlying pathology. In this study, we demonstrate that inhomogeneous magnetization transfer (ihMT) can detect residual non-compact myelin in the context of hypercellular white matter in the dysmyelinating shiverer mouse model with optimized imaging parameters, whereas conventional MT show no apparent contrast. This result suggests that ihMT has higher sensitivity to myelin than conventional MT in the presence of cell infiltrations.
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