Abstract #3706

Amide proton transfer-weighted MR imaging in the rat brain of demyelination and remyelination

Do-Wan Lee¹, Hwon Heo², Chul‐Woong Woo³, Jae-Im Kwon³, Joongkee Min³, Monica Young Choi², Yeon Ji Chae², Dong‐Cheol Woo^2,3, Kyung Won Kim¹, Jeong Kon Kim¹, Hyo Jeong Chin⁴, and Dong‐Hoon Lee⁴

¹Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Radiological Science, College of Health Sciences, Yonsei University, Wonju, Korea, Republic of

Investigations of amide proton signal changes in the white matter of demyelinating diseases may provide important biophysical information for diagnostic and prognostic assessments. We attempted to evaluate in vivo APT_w signal changes within the CC in a reversible cuprizone-induced demyelination rat model using amide proton transfer-weighted (APT_w) MRI at 7-T. We also used immunohistochemical staining to characterize demyelinating and remyelinating activity in the CC following myelin and axon changes. Significant APT_w metric changes coupled with the histological characteristics of the demyelination and remyelination processes indicate the potential usefulness of APT_w 7T MRI to monitor earlier myelination processes.

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