Investigations of amide proton signal changes in the white matter of demyelinating diseases may provide important biophysical information for diagnostic and prognostic assessments. We attempted to evaluate in vivo APTw signal changes within the CC in a reversible cuprizone-induced demyelination rat model using amide proton transfer-weighted (APTw) MRI at 7-T. We also used immunohistochemical staining to characterize demyelinating and remyelinating activity in the CC following myelin and axon changes. Significant APTw metric changes coupled with the histological characteristics of the demyelination and remyelination processes indicate the potential usefulness of APTw 7T MRI to monitor earlier myelination processes.
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