Abstract #3705

Potential feasibility of new parameters on CEST imaging by multi pool model in relation to 11C-MET uptake on PET/CT and IDH1 mutation in gliomas

Yasukage Takami¹, Naruhide Kimura¹, Katsuya Mitamura¹, Takashi Norikane¹, Keisuke Miyake², Tatsuya Yamasaki³, Kazuo Ogawa³, Mitsuharu Miyoshi⁴, and Yoshihiro Nishiyama¹

¹Department of Radiology, Faculty of Medicine, Kagawa University, Miki-cho, Japan, ²Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Miki-cho, Japan, ³Department of Clinical Radiology, Kagawa University Hospital, Miki-cho, Japan, ⁴Global MR Applications & Workflow, GE Healthcare Japan, Hino-shi, Japan

The purpose of this study was to evaluate the correlation between parameters on CEST imaging by multi pool model and ¹¹C-methionine (MET) uptake on PET/CT in gliomas. The maximum and mean values of the parameters on CEST imaging were measured. ¹¹C-MET uptake was semiquantitatively assessed using tumor-to-contralateral normal brain tissue (T/N) ratio. Several correlation coefficients between MTRasym and T/N ratio, and APT_T1 and MET T/N ratio were relatively high, but not statistically significant. These preliminary results suggest that parameters on CEST imaging by multi pool model seems to correlate with ¹¹C-MET uptake on PET/CT in patients with gliomas.

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