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Abstract #3704

Discrimination of IDH1 Genotype and 1p/19q Status in Glioma: A comparison study between Arterial Spin Labeling and Amide Proton Transfer imaging

DiaoHan Xiong1, Rui Wang1, Tao Wen1, Yujing Li1, Xinying Ren1, Pengfei Wang1, Guangyao Liu1, Jing Zhang1, and Kai Ai2
1Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, 2Philips Healthcare, Xi'an, China

We investigated the association of amide proton transfer weighted imaging (APTw) and 3D arterial spin label (3D-pCASL) with IDH1 Genotype and 1p/19q Status in gliomas,then compared the two methods. All patients underwent MR examination, including APT and 3D-pCASL scan to get their values of the solid part. The results showed both APTw and 3D-pCASL had predictive values on IDH1 Genotype and 1p/19q Status in gliomas, and the performance of 3D-pCASL was better. We conclude that both APTw and 3D-pCASL can be used to predict the gene type of IDHin high-grade and 1p/19q co-deletion of gliomas before surgery, meanwhile 3D-pCASL is the better choice.

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