Discrimination of IDH1 Genotype and 1p/19q Status in Glioma: A comparison study between Arterial Spin Labeling and Amide Proton Transfer imaging

We investigated the association of amide proton transfer weighted imaging (APTw) and 3D arterial spin label (3D-pCASL) with IDH1 Genotype and 1p/19q Status in gliomas，then compared the two methods. All patients underwent MR examination, including APT and 3D-pCASL scan to get their values of the solid part. The results showed both APTw and 3D-pCASL had predictive values on IDH1 Genotype and 1p/19q Status in gliomas, and the performance of 3D-pCASL was better. We conclude that both APTw and 3D-pCASL can be used to predict the gene type of IDHin high-grade and 1p/19q co-deletion of gliomas before surgery, meanwhile 3D-pCASL is the better choice.