Abstract #3710

Differentiating PD and MSA-P with Neuromelanin and Iron Simultaneously Using a Single 3D Magnetization Transfer Sequence

Yu Liu¹, Junchen Li², Ying Wang³, Naying He¹, Zhijia Jin¹, Pei Huang⁴, Shengdi Chen⁴, Fuhua Yan¹, and Ewart Mark Haacke³

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Radiology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China, ³Wayne State University, Detroit, MI, United States, ⁴Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

MSA with a parkinsonian variant (MSA-P) and PD share many common clinical presentations, such as parkinsonism and autonomic failure to mention just a few. The early differential diagnosis of these two disorders has been established more or less empirically despite a lack of a subjective, satisfactory biomarker. Neuroimaging has revolutionized in-vivo visualization of neuromelanin and iron in the substantial nigra (SN), which has been considered as the primary and predominant pathophysiological change in PD patients. We found significant neuromelanin changes in the SN in patients with MSA-P compared with PD and HC.

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