Glioblastoma multiforme has been reported to rely both on glycolysis and oxidative metabolism but methods are lacking to assess such heterogenity in vivo. We previously showed a novel application of Marchenko–Pastur PCA denoising (MP-PCA) to dynamic glucose-enhanced deuterium MRS (DGE 2H-MRS). Here, we use this approach to measure glycolytic and oxidative metabolic turnover rates in mouse glioma, thereby assessing their functional metabolic heterogeneity. This methodology can be extended to other cancer models and is available for clinical translation, holding strong potential for improving non-invasive cancer phenotyping and/or assessment of early therapeutic response.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords