Abstract #3717

Simultaneous 3D 1H-MRSI and PET Imaging Associates Neurometabolism with Beta-amyloid Aggregation in Alzheimer's Disease

Jialin Hu¹, Miao Zhang², Yaoyu Zhang¹, Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Ziyu Meng¹, Biao Li², Jun Liu⁵, Binyin Li⁵, Jie Luo¹, Chao Ma⁶, Georges El Fakhri⁶, Zhi-Pei Liang^3,4, and Yao Li¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁶Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Beta-amyloid (Aβ) aggregation and neurometabolic changes are biomarkers for Alzheimer’s disease (AD) at early stage. But their underlying relationship in association with AD pathology is still not fully understood. In this study, we simultaneously acquired 3D high-resolution MRSI using SPICE and ¹⁸F-AV45-PET images on a PET-MR scanner. Concurrent changes in neurometabolite concentrations and Aβ deposition in healthy control, mild cognitive impairment, and AD groups were compared. An increase in myo-inositol and a decrease in N-acetylaspartate were found as dementia became more severe. Our findings may lay a foundation for further investigation of AD pathogenesis using multimodal metabolic imaging.

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