The commonly used granger causality (GC) and the metabolic effective connection (MEC) methods, had been compared the efficacy in identifying the directional pathways of dopamine system on the base of simultaneous PET/MR data. GC and MEC both identified different directed pathways of dopamine system. GC identified more long pathways from cortex to nucleus than MEC, while MEC did better job in identifying subtentorial pathways. The unidirectional frontostriatal pathways identified by MEC was more inline with existing researches than GC, the latter reported bidirectional interaction pathways there. MEC was recommended in region-wise research when PET/MR is available.
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