Abstract #3715

Multimodal 1H-MRSI and 18F-FDG-PET in Temporal Lobe Epilepsy

Lihong Tang¹, Hui Huang¹, Miao Zhang², Yibo Zhao^3,4, Rong Guo^3,4, Yudu Li^3,4, Zhi-Pei Liang^3,4, Wei Liu⁵, Yao Li¹, Biao Li², and Jie Luo¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Electrical and Computer Engineering, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁴Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana Champaign, Urbana, IL, United States, ⁵Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

NAA decrease and FDG low uptake in cortical and subcortical regions of the limbic system are among the most common findings in temporal lobe epilepsy (TLE) patients. In addition, tissue susceptibility changes in the deep nuclei, myelin water fraction and NAA decrease in white matter bundles might offer complementary information for lateralization. We demonstrated the feasibility of simultaneous high-resolution 1H-MRSI (2.0 x 3.0 x 3.0 mm³), MWF, QSM, and ¹⁸F-FDG-PET and investigated potential of the multimodal information for detecting metabolic and microstructural changes in subcortical, cortical and white matter regions for TLE, with results consistent with literature for each modality.

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