Abstract #3714

GABA Inhibition Enhances in Epilepsy Associated with Focal Cortical Dysplasia

Tao Gong¹, Yufan Chen¹, Liangjie Lin², Youting Lin³, and Guangbin Wang¹

¹Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, ²Philips Healthcare, Beijing, China, ³Departments of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

The aim of this study was to investigate the metabolic dysfunction of FCD associated epilepsy using Edited MRS. 14 patients and 14 age- and sex-matched healthy controls underwent MR scans, including Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy (HERMES). The results indicated that GABA levels were significantly increased in epilepsy focal region of patients compared with contralateral regions and healthy controls, while no significant alterations were found in GSH and Glx levels. GABAergic inhibition enhances in FCD foci suggested that GABA may play a central role in the pathophysiology of FCD associated epilepsy.

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