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Abstract #3714

GABA Inhibition Enhances in Epilepsy Associated with Focal Cortical Dysplasia

Tao Gong1, Yufan Chen1, Liangjie Lin2, Youting Lin3, and Guangbin Wang1
1Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, 2Philips Healthcare, Beijing, China, 3Departments of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

The aim of this study was to investigate the metabolic dysfunction of FCD associated epilepsy using Edited MRS. 14 patients and 14 age- and sex-matched healthy controls underwent MR scans, including Hadamard Encoding and Reconstruction of Mega-Edited Spectroscopy (HERMES). The results indicated that GABA levels were significantly increased in epilepsy focal region of patients compared with contralateral regions and healthy controls, while no significant alterations were found in GSH and Glx levels. GABAergic inhibition enhances in FCD foci suggested that GABA may play a central role in the pathophysiology of FCD associated epilepsy.

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