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Abstract #3713

Fast High-Resolution 1H-MRSI of the Human Brain at 7T

Rong Guo1,2, Yibo Zhao1,2, Yudu Li1,2, Pallab Bhattacharyya3, Mark Lowe3, Hannes M. Wiesner 4, Yao Li5, Xiao-Hong Zhu4, Wei Chen4, and Zhi-Pei Liang1,2
1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 5School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Ultrahigh field systems provide significant SNR benefits to MRSI, but also bring new challenges for accelerated MRSI due to increased spectral bandwidth and larger B0/B1 inhomogeneities. We have managed to overcome these problems and developed a SPICE-based data acquisition and processing technique for rapid, high-resolution spectroscopic imaging of the human brain without water-suppression at 7T. The proposed method can simultaneously obtain metabolite signals at 3.0×3.0×3.0 mm3 resolution and companion water signals at 1.0×1.0×3.0 mm3 resolution with high SNR in a single 8 min scan.

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