Abstract #3713

Fast High-Resolution 1H-MRSI of the Human Brain at 7T

Rong Guo^1,2, Yibo Zhao^1,2, Yudu Li^1,2, Pallab Bhattacharyya³, Mark Lowe³, Hannes M. Wiesner ⁴, Yao Li⁵, Xiao-Hong Zhu⁴, Wei Chen⁴, and Zhi-Pei Liang^1,2

¹Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ⁵School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Ultrahigh field systems provide significant SNR benefits to MRSI, but also bring new challenges for accelerated MRSI due to increased spectral bandwidth and larger B₀/B₁ inhomogeneities. We have managed to overcome these problems and developed a SPICE-based data acquisition and processing technique for rapid, high-resolution spectroscopic imaging of the human brain without water-suppression at 7T. The proposed method can simultaneously obtain metabolite signals at 3.0×3.0×3.0 mm³ resolution and companion water signals at 1.0×1.0×3.0 mm³ resolution with high SNR in a single 8 min scan.

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