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Abstract #3712

Prediction of the response to induction chemotherapy using Amide Proton Transfer MRI in nasopharyngeal carcinoma

Guixiao Xu1, Hui Li1, Yueming Yuan2, Liangru Ke1, Yun He1, Yanlin Zhu1, Liyun Zhen2, Yingyi Huang1, Chuanmiao Xie1, and Yongming Dai2
1Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangzhou, China, 2Central Research Institute, United Imaging Healthcare, Shanghai, China

Nasopharyngeal carcinoma (NPC) prevails in Southeast Asia. Induction chemotherapy (IC) is recommended as the effective treatment for patients with NPC. However, not all patients respond well to IC. Pretreatment identification of the non-responders may help to make treatment more personalized. The amide proton transfer (APT) MRI can give contrast due to exchangeable backbone amide protons of endogenous mobile proteins and peptides, and APT value in tumor has been reported higher. Therefore, the aim of this study is to evaluate whether APT value before treatment correlate to IC response in NPC.

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