Abstract #3720

Evaluation of the agreement of metabolite levels between PRESS and MEGA-PRESS techniques in the grading of glioma patients

Gerd Melkus^1,2, Michael Taccone^3,4, Ioana D Moldovan^4,5, John Woulfe^3,5,6, Gerard Jansen^3,7, Ian Cameron^1,2, Fahad AlKherayf^3,4,5, and Thanh Binh Nguyen^1,2

¹Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, ²Radiology, University of Ottawa, Ottawa, ON, Canada, ³University of Ottawa, Ottawa, ON, Canada, ⁴Division of Neurosurgery, The Ottawa Hospital, Ottawa, ON, Canada, ⁵The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁶Division of Neurology, University of Ottawa, Ottawa, ON, Canada, ⁷Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada

The main objective of this study is to evaluate the agreement of metabolites between the MEGA-PRESS sequence (analyzing the edit-off spectrum) and a standard long TE PRESS sequence that is used in clinical routine for tumour characterization. The T2 corrected metabolite levels of NAA, Cho and Cr obtained from the edit-off spectrum of the MEGA-PRESS sequence are in good agreement with those obtained from the standard long TE PRESS sequence. No significant difference in the diagnostic accuracy was found.

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