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Abstract #3721

Quantification of neurobiological responses in the hippocampus: Towards in vivo neurochemical profiling of cuprizone-induced demyelination

Do-Wan Lee1, Yeon Ji Chae2, Monica Young Choi2, Jae-Im Kwon3, Joongkee Min3, Chul‐Woong Woo3, Hwon Heo2, Dong‐Cheol Woo2,3, Jeong Kon Kim1, Kyung Won Kim1, Hyo Jeong Chin4, and Dong‐Hoon Lee4
1Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, 2Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, 3Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, 4Department of Radiological Science, College of Health Sciences, Yonsei University, Wonju, Korea, Republic of

This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo proton magnetic resonance spectroscopy (1H-MRS) at 7-T. The principal findings of the present study were significantly altered concentrations of gamma-aminobutyric acid, glutamate, myo-Inositol, tCr (creatine + phosphocreatine), and Glx (glutamate + glutamine) in the hippocampus of the demyelination-induced rats relative to those in control rats. Our results showed that cuprizone-induced neuronal demyelination may influence the severe abnormal metabolism in hippocampal lesions, and these responses could be caused by microglial activation, mitochondrial dysfunction, and astrocytic necrosis.

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