Abstract #3721

Quantification of neurobiological responses in the hippocampus: Towards in vivo neurochemical profiling of cuprizone-induced demyelination

Do-Wan Lee¹, Yeon Ji Chae², Monica Young Choi², Jae-Im Kwon³, Joongkee Min³, Chul‐Woong Woo³, Hwon Heo², Dong‐Cheol Woo^2,3, Jeong Kon Kim¹, Kyung Won Kim¹, Hyo Jeong Chin⁴, and Dong‐Hoon Lee⁴

¹Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Radiological Science, College of Health Sciences, Yonsei University, Wonju, Korea, Republic of

This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo proton magnetic resonance spectroscopy (¹H-MRS) at 7-T. The principal findings of the present study were significantly altered concentrations of gamma-aminobutyric acid, glutamate, myo-Inositol, tCr (creatine + phosphocreatine), and Glx (glutamate + glutamine) in the hippocampus of the demyelination-induced rats relative to those in control rats. Our results showed that cuprizone-induced neuronal demyelination may influence the severe abnormal metabolism in hippocampal lesions, and these responses could be caused by microglial activation, mitochondrial dysfunction, and astrocytic necrosis.

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