Abstract #3722

Simultaneous Myelin Water Imaging and 3D 1H-MRSI Relates Myelin Degradation to Neurometabolic Changes in Mild Traumatic Brain Injury Patients

Tianyao Wang¹, Danni Wang², Yujie Hu², Rong Guo^3,4, Yudu Li^3,4, Yibo Zhao^3,4, Jun Liu⁵, Zhi-Pei Liang^3,4, and Yao Li²

¹Radiology Department, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China, ²School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ³Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Radiology Department, Tong Ren Hospital Shanghai Jiao Tong University School Medicine, Shanghai, China

White matter tracts are known to be highly vulnerable to traumatic axonal injury. Myelin degradation is a major contributing factor for the white matter pathology in traumatic brain injury (TBI), but its relation to neurometabolite alterations is unclear. In this study, we used the latest SPICE technology to perform simultaneous 3D high-resolution MRSI and myelin water imaging to assess the relationship between myelin degradation and neurometabolic changes in acute mild TBI (mTBI) patients. Our results showed coupled MWF and NAA reductions in occipital CC tract of the patients, which provides new insights into TAI pathology in acute mTBI.

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