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Abstract #3723

Biochemical and behavioral alterations in a ferret model of blast related mild traumatic brain injury

Shiyu Tang1,2, Su Xu1,2, Donna Wilder3, Joseph Long3, Venkata Siva Sai Sujith Sajja3,4, and Rao Gullapalli1,2
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Center for Advanced Imaging Research (CAIR), University of Maryland School of Medicine, Baltimore, MD, United States, 3Blast Induced Neurotrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States, 4The Geneva Foundation, Tacoma, WA, United States

We studied the longitudinal changes in brain metabolism and impulsivity behavior in ferrets, a gyrencephalic animal model subjected to novel blast exposure conditions that closely mimic those encountered by Warfighters. Compared to rodents, the ferret model has greater similarities to human in terms of developmental process, brain structure and sophisticated behavior. Ferrets demonstrated increased behavioral impulsivity and higher glutamate and taurine in prefrontal cortex following blast exposure. Our findings are in agreement with clinical observations in patients, suggesting that this model is a good gyrencephalic animal model to study brain biochemical profile changes and neuropsychiatric alterations associated with blast exposure.

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