Meeting Banner
Abstract #3728

Upper brainstem GABA levels in Parkinson’s disease

Yulu Song1, Tao Gong1, Muhammad G. Saleh2,3, Mark Mikkelsen2,3, Guangbin Wang 1, and Richard Edden2,3
1Shandong Medical Imaging Research Institute, Shandong University, jinan, China, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, baltimore, MD, United States, 3FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, baltimore, MD, United States

The aim of this study is to test the hypothesis that levels of gamma-aminobutyric acid (GABA) in the upper brainstem are reduced in patients with PD compared to healthy controls, using edited magnetic resonance spectroscopy (MRS of GABA+). GABA+-edited MRS was performed in 7.5-ml voxels in the upper brainstem in 18 PD patients and 18 age- and sex-matched healthy controls (HCs), and the spectra were processed using the Gannet software. The lower GABA+ levels in the upper brainstem of the PD patients suggest that a GABAergic deficit in the brainstem may contribute to the dopaminergic pathology in PD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here