Abstract #3729

In vivo detection of GSH in the mouse brain using MEGA-PRESS at 9.4T

David Jing Ma¹, Sabrina Gjerswold-Selleck², Yanping Sun³, Matt Mattingly Mattingly⁴, and Jia Guo⁵

¹Biomedical Engineering, Columbia University, New York, NY, United States, ²Columbia University, New York, NY, United States, ³Herbert Irving Comprehensive Cancer Centre, Columbia University, New York, NY, United States, ⁴Bruker BioSpin, Billerica, MA, United States, ⁵Department of Psychiatry, Columbia University, New York, NY, United States

Glutathione (GSH) is an important intracellular antioxidant in the brain. Various clinical human studies report its measurement by localized ¹H spectroscopy using MEGA-PRESS and achieve high reliability and accuracy of GSH measurements at 3 T. As of today, animal model studies conducted at higher fields significantly enhance the armamentarium of tools available for the probing brain function and brain pathologies. However, even though mice are widely used in research, limited studies of GSH in mouse models are conducted. In this study, we demonstrate that MEGA-PRESS is a feasible technique to measure GSH in the mouse brain in vivo at 9.4T.

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