Abstract #3730

Reproducibility of metabolite measurements in the preterm brain using magnetic resonance spectroscopy

Subechhya Pradhan^1,2,3, Sudeepta Basu⁴, Kushal Kapse¹, Devon Fisher¹, Stephanie Norman¹, and Catherine Limperopoulos^1,2,3

¹Developing Brain Institute, Children's National Hospital, Washington, DC, United States, ²Radiology, Pediatrics, George Washinton University, Washington, DC, United States, ³Radiology and Diagnostic Imaging, Children's National Hospital, Washington, DC, United States, ⁴Neonatalogy, Children's National Hospital, Washington, DC, United States

Preterm brain metabolism studies using magnetic resonance spectroscopy (MRS) demonstrate an association between abnormal biochemistry and brain injury. To our knowledge, there are no reports on the reproducibility of these measurements as well as the optimal pulse sequence to measure each metabolite in the preterm brain. In this study, results of same-session reproducibility of metabolite concentration measurements from 15 preterm scanning sessions using 4 different pulse sequences are presented.

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