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Abstract #3731

Quantitative measurement of changes in 23Na MRI following transcranial direct current stimulation (tDCS) of the motor cortex

Iris Asllani1,2, Francesco Di Lorenzo1, Balazs Orzsik1, Guillaume Madelin3, Neil Harrison4, and Mara Cercignani1
1University of Sussex, Brighton, United Kingdom, 2Rochester Institute of Technology, Rochester, NY, United States, 3New York University, New York, NY, United States, 4University of Cardiff, Cardiff, United Kingdom

23Na MRI data were acquired on healthy volunteers ~15 mins after either anodal, cathodal, or sham application of tDCS in the motor cortex. Tissue specific [Na] concentration images were obtained using a partial volume correction algorithm previously developed for ASL MRI. There was an average 14% increase in gray matter sodium concentration, [Na]GM, across the group following the anodal tDCS; no significant change was observed for the sham application. Of note, all subjects exhibited a widespread pattern of increased [Na]GM similar to that reported in ASL MRI studies that have measured changes in CBF also following anodal tDCS of M1.

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