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Abstract #3791

Establishing the Structurally Limited Healthy RBC to Barrier Ratio for 129Xe Gas Exchange MRI

Bastiaan Driehuys1 and Elianna Ada Bier2
1Radiology, Duke University, Durham, NC, United States, 2Biomedical Engineering, Duke University, Durham, NC, United States

In quantitative 129Xe gas exchange MRI, the RBC/barrier ratio is emerging as a robust and important functional metric. However, it depends strongly on how it is measured, specifically on flip angle and repetition time. Moreover, we don’t yet have a clear understanding of its expected range in healthy subjects. Here, we demonstrate that by combining a physical diffusion model of 129Xe signal recovery with the recently introduced concept of flip angle to TR-equivalence, we can estimate the “structural limit” for the maximum RBC/barrier ratio expected in healthy adult subjects at any TR and flip angle.

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