Fractional ventilation, a metric denoting per-breath pulmonary gas replacement, has been shown to be sensitive to disease-induced alterations in ventilation in diseases such as emphysema. We have developed two discrete techniques for measuring FV using hyperpolarized 129Xe MR imaging and demonstrated their acquisition in a rat. Although the two techniques yield different FV maps, these two techniques offer both a quick and cost-effective method and a longer, robust method for probing pulmonary ventilation.
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