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Abstract #3795

Optimized Magnetization Decay Correction of Hyperpolarized 129Xe Ventilation Images Using Radial-Keyhole

Mariah L. Costa1,2, Peter J. Niedbalski3, Matthew M. Willmering1, and Zackary I. Cleveland1,2,4
1Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States, 4Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Advances in hyperpolarization (HP) technology have expanded the translation and clinical utility of HP media MR. Unfortunately, HP images suffer from artifacts and inaccuracies due to magnetization decay. To mitigate decay, we introduced a method to map magnetization dynamics via Bloch-equation modeling and keyhole reconstruction. Here we extend the approach to include optimization via uncertainty propagation. As proof-of-principle, we compared a linear and interleaved keyhole to map HP decay in digital phantoms and 129Xe ventilation images. Linear keyhole yielded uniform decay values, while interleaved keyhole generated physically improbable distributions, demonstrating the utility of analytical optimization in radial-keyhole decay correction.

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