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Abstract #3796

Simulating the impact of asymmetric geometries on apparent alveolar septal wall thickness measurements with hyperpolarized xenon-129 MRI

Yiwen Qian1, Kai Ruppert1, Faraz Amzajerdian1, Yi Xin1, Hooman Hamedani1, Luis Loza1, Tahmina S Achekzai1, Ryan J Baron1, Ian F Duncan1, Stephen Kadlecek1, and Rahim R Rizi1
1University of Pennsylvania, Philadelphia, PA, United States

Measurement of the apparent alveolar septal wall thickness (SWT) via chemical shift saturation recovery (CSSR) with hyperpolarized xenon-129 is emerging as a robust and sensitive technique for detecting lung disease. However, the extracted pulmonary physiological values are obtained by fitting theoretical gas uptake curves that are based on assumptions of an unrealistically symmetric alveolar anatomy to the measurement data. In this work, we investigated the impact of asymmetric septal walls on the fitting parameters using numerically simulated CSSR measurement data. Our simulations predict potentially large errors in all fitting parameters other than the total septal wall thickness.

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