Abstract #3797

3D Multi-slice hyperpolarized 129Xe imaging of the human brain

Vira Grynko^1,2, Yurii Shepelytskyi^1,2, Tao Li³, Ayman Hassan^4,5, Karl Granberg⁴, and Mitchell S. Albert^2,3,5

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Chemistry Department, Lakehead University, Thunder Bay, ON, Canada, ⁴Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada, ⁵Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Hyperpolarized (HP) ¹²⁹Xe magnetic resonance imaging (MRI) of the brain can be used to evaluate cerebral perfusion. Currently, all HP ¹²⁹Xe brain imaging techniques were only performed for single slice imaging. To further develop clinical applications of functional HP ¹²⁹Xe brain imaging, multi-slice acquisitions are necessary. In this work, we demonstrate the capability of multi-slice human brain imaging with HP ¹²⁹Xe using 3D gradient echo imaging with a Cartesian readout. This will allow further progress in various HP ¹²⁹Xe functional brain imaging applications such as perfusion evaluation and hemodynamic response detection.

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