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Abstract #3797

3D Multi-slice hyperpolarized 129Xe imaging of the human brain

Vira Grynko1,2, Yurii Shepelytskyi1,2, Tao Li3, Ayman Hassan4,5, Karl Granberg4, and Mitchell S. Albert2,3,5
1Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 3Chemistry Department, Lakehead University, Thunder Bay, ON, Canada, 4Thunder Bay Regional Health Sciences Centre, Thunder Bay, ON, Canada, 5Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Hyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) of the brain can be used to evaluate cerebral perfusion. Currently, all HP 129Xe brain imaging techniques were only performed for single slice imaging. To further develop clinical applications of functional HP 129Xe brain imaging, multi-slice acquisitions are necessary. In this work, we demonstrate the capability of multi-slice human brain imaging with HP 129Xe using 3D gradient echo imaging with a Cartesian readout. This will allow further progress in various HP 129Xe functional brain imaging applications such as perfusion evaluation and hemodynamic response detection.

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