Abstract #3798

Molecular translation in inhomogeneous field can dramatically reduce the efficiency of spin-order transfer at high field

Vladislav Ivantaev¹, Stephan Berner^1,2,3, Henri de Maissin¹, Jan-Bernd Hövener ⁴, Jürgen Hennig¹, Dominik v. Elverfeldt¹, Valerij G. Kiselev¹, and Andreas B. Schmidt^1,2,3

¹Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany, ²German Consortium for Cancer Research (DKTK), partner site Freiburg, Freiburg, Germany, ³German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Section Biomedical Imaging, Department of Radiology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

Parahydrogen induced polarization (PHIP) allows providing hyperpolarized (HP) agents for metabolic MRI within seconds and at negligible cost. Recently, we demonstrated PHIP inside of an MRI system using spin-order transfer (SOT) sequences and showed direct in-vivo administration of the agent without transport. Here, we show that molecular translational motion in the inhomogeneous field of the MRI during SOT can strongly corrupt the HP yield. While we already demonstrated signal enhancement of ¹³C of 40.000-fold at 7 Tesla with our method, we suggest that the HP can be further improved by a better field homogeneity and reduced motion during the SOT.

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