Parahydrogen induced polarization (PHIP) allows providing hyperpolarized (HP) agents for metabolic MRI within seconds and at negligible cost. Recently, we demonstrated PHIP inside of an MRI system using spin-order transfer (SOT) sequences and showed direct in-vivo administration of the agent without transport. Here, we show that molecular translational motion in the inhomogeneous field of the MRI during SOT can strongly corrupt the HP yield. While we already demonstrated signal enhancement of 13C of 40.000-fold at 7 Tesla with our method, we suggest that the HP can be further improved by a better field homogeneity and reduced motion during the SOT.
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