Deoxy-D-glucose (2-DG) is a synthetic glucose analog, which inhibits the first step in the glycolysis by inhibiting the enzyme hexokinase. It has been shown to increase chemosensitivity in some cancers and to reverse glucocorticoid resistance in acute lymphoblastic leukemia. This could have potential for treatment in other leukemia diseases. The present study investigates whether hyperpolarized 13C-MR can be used to explore into the effect of 2-DG and lactate on cell metabolism in acute myeloblastic leukemia cells.
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