Longitudinal relaxation time constants of hyperpolarized [1-13C]pyruvate, [13C,15N2]urea and [2-13C]dihydroxyacetone in whole bovine blood were measured via low excitation angle dynamic pulse-acquire NMR spectroscopy at 7T. A small lactate signal was produced in scans of pyruvate, corresponding to <1% of the pyruvate precursor signal. All three 13C agents demonstrated shorter T1 relaxation time constants in blood with arterial oxygen content than in blood with venous oxygenation, and the greatest oxygen-accelerated relaxation effect was observed for pyruvate.
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