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Abstract #3800

Effects of Blood Oxygen Content on Longitudinal Relaxation of Hyperpolarized 13C Agents at 7 Tesla

Keith Michel1, Collin Harlan1, Trevor Mitcham1, Matthew Merritt2, Richard Bouchard1, and James Bankson1
1Imaging Physics, UT MD Anderson Cancer Center, Houston, TX, United States, 2Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States

Longitudinal relaxation time constants of hyperpolarized [1-13C]pyruvate, [13C,15N2]urea and [2-13C]dihydroxyacetone in whole bovine blood were measured via low excitation angle dynamic pulse-acquire NMR spectroscopy at 7T. A small lactate signal was produced in scans of pyruvate, corresponding to <1% of the pyruvate precursor signal. All three 13C agents demonstrated shorter T1 relaxation time constants in blood with arterial oxygen content than in blood with venous oxygenation, and the greatest oxygen-accelerated relaxation effect was observed for pyruvate.

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