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Abstract #3801

Hyperpolarized 13C Spectroscopy with Simple Slice-and-Frequency-Selective Excitation

Geoffrey J. Topping1, Irina Heid2, Marija Trajkovic-Arsic3,4, Lukas Kritzner2, Martin Grashei1, Christian Hundshammer1, Maximilian Aigner1, Jason G. Skinner1, Rickmer Braren2, and Franz Schilling1
1Department of Nuclear Medicine, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Diagnostic and Interventional Radiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 3German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), West German Cancer Center, University Hospital Essen, Essen, Germany

A narrow-bandwidth alternating-frequency multi-frame slice-selective-excitation FID spectroscopy sequence was implemented with minimal pulse sequence modification by prescribing spatially offset slices. This sequence was used to measure hyperpolarized [1‑13C]lactate and its downstream metabolite [1‑13C]pyruvate in a xenograft rat model of human pancreatic cancer (PSN1). Broad bandwidth excitation has difficulty separating the smaller pyruvate peak from the larger peak of injected lactate, when analyzed with magnitude spectra, phased complex spectra, or spectral fitting with the AMARES algorithm, particularly for multi-frame data. Narrow bandwidth excitation spectroscopy is simpler and more consistent to analyze, by achieving the spectral separation during acquisition.

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