A narrow-bandwidth alternating-frequency multi-frame slice-selective-excitation FID spectroscopy sequence was implemented with minimal pulse sequence modification by prescribing spatially offset slices. This sequence was used to measure hyperpolarized [1‑13C]lactate and its downstream metabolite [1‑13C]pyruvate in a xenograft rat model of human pancreatic cancer (PSN1). Broad bandwidth excitation has difficulty separating the smaller pyruvate peak from the larger peak of injected lactate, when analyzed with magnitude spectra, phased complex spectra, or spectral fitting with the AMARES algorithm, particularly for multi-frame data. Narrow bandwidth excitation spectroscopy is simpler and more consistent to analyze, by achieving the spectral separation during acquisition.
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