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Abstract #3802

Hyperpolarized 13C Imaging Using a Custom-built 13C Jacket Coil in a 3 T GE Scanner

GUANNAN ZHANG1, Kofi Deh1, Avigdor Leftin2, and Kayvan R. Keshari1,3
1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2GE Healthcare, New York, NY, United States, 3Weill Cornell Graduate School, New York, NY, United States

Hyperpolarized MRI using [1-13C] pyruvate is a novel technique that has been safely performed in humans for cancer studies. Here, we present preliminary work on acquiring dynamics of hyperpolarized [1-13C] pyruvate images using a custom-built 13C jacket coil, demonstrating the applicability of the method to image patients with metastatic cancer in the abdomen. The jacket coil provides coverage and RF excitation over the whole abdominal area, allowing to detect the spread of the metastatic cancer. The hyperpolarized 13C images acquired by a spiral sequence show a good quality, demonstrating the feasibility of the method for future hyperpolarization studies in patients.

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