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Abstract #3803

Slowing T1 relaxation of hyperpolarized [2-13C]pyruvate with deuterium enrichment

Albert P Chen1, Kayvan R Keshari2, and Charles H Cunningham3
1GE Healthcare, Toronto, ON, Canada, 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

The effect of deuterium enrichment on T1 relaxation was investigated for hyperpolarized [2-13C]pyruvate. The T1 increased by 10s at 3T with deurterium enrichment on the sample molecule. The T1 further increased by almost 30s when the hyperpolarized sample was dissolved using D2O instead of H2O. Deuterium enrichment of the substrate and the dissolution media has the potential to significantly increase the available non-equilibrium polarization available at the time of injection for dissolution DNP experiments.

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