Hyperpolarized MR studies of localized animal disease models, specifically our studies of cerebral metabolism after transient ischemia in a mouse model of stroke, are greatly improved by implementation of spatially resolved measurements. The latter allows unfolding specific metabolic alterations in core, penumbra and peripheral tissues taking place after ischemia. To achieve higher specificity, the performances of a DNP polarizer were improved by installing a custom fluid path dissolution system to achieve higher polarization levels. In parallel, we implemented a dynamic spiral acquisition sequence to enable time-resolved MR metabolic imaging. Herein, we present our preliminary in-vivo proof of principle.
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