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Abstract #3804

Hyperpolarized in-vivo Metabolic Imaging at 14.1T: dDNP Cryogenic Insert Redesign and Implementation

Thanh Phong Lê1,2, Andrea Capozzi2,3, and Jean-Noël Hyacinthe1,4
1Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, 2Laboratory of Functional and Metabolic Imaging, EPFL (Swiss Federal Institute of Technology in Lausanne), Lausanne, Switzerland, 3Department of Health Technology, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Kongens Lyngby, Denmark, 4Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Hyperpolarized MR studies of localized animal disease models, specifically our studies of cerebral metabolism after transient ischemia in a mouse model of stroke, are greatly improved by implementation of spatially resolved measurements. The latter allows unfolding specific metabolic alterations in core, penumbra and peripheral tissues taking place after ischemia. To achieve higher specificity, the performances of a DNP polarizer were improved by installing a custom fluid path dissolution system to achieve higher polarization levels. In parallel, we implemented a dynamic spiral acquisition sequence to enable time-resolved MR metabolic imaging. Herein, we present our preliminary in-vivo proof of principle.

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