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Abstract #3805

Dramatic Effect of Pulse Length and Bandwidth on the Efficiency of Pulsed Spin-Order-Transfer Sequences at High Field.

Henri de Maissin1, Stephan Berner2, Vladislav Vladislav Ivantaev3, Jan Hövener4, Jürgen Hennig5, Dominik von Elverfeldt5, and Andreas Schmidt6
1Radiology, Uniiklinik Freiburg, Freiburg, Germany, 2radiology, Uniklinik Freiburg, Freiburg, Germany, 3radiology, Uniklinik freiburg, freiburg, Germany, 4hyperpolarization, Kiel university, Kiel, Germany, 5radiology, Uniklinik Freiburg, freiburg, Germany, 6Radiology, Uniklinik Freiburg, freiburg, Germany

Para-Hydrogen Induced Polarization (PHIP) is a promising cost- and time-efficient technique for highly-sensitive metabolic MRI. We recently demonstrated PHIP with 13C-polarizations of 25% inside MRI systems at high field using spin-order transfer (SOT) sequences. Here, we show that SOT is extremely sensitive to limited proton-RF bandwidth available in MRI setups. This effect is crucial for hyperpolarization of metabolic agents like acetate and pyruvate; and for PHIP in human MRI setups, dedicated hardware may be required. Still, high-field PHIP is promising as the setup is inexpensive and simple and requires no transport of the agents to the MRI system is needed.

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