Abstract #3805

Dramatic Effect of Pulse Length and Bandwidth on the Efficiency of Pulsed Spin-Order-Transfer Sequences at High Field.

Henri de Maissin¹, Stephan Berner², Vladislav Vladislav Ivantaev³, Jan Hövener⁴, Jürgen Hennig⁵, Dominik von Elverfeldt⁵, and Andreas Schmidt⁶

¹Radiology, Uniiklinik Freiburg, Freiburg, Germany, ²radiology, Uniklinik Freiburg, Freiburg, Germany, ³radiology, Uniklinik freiburg, freiburg, Germany, ⁴hyperpolarization, Kiel university, Kiel, Germany, ⁵radiology, Uniklinik Freiburg, freiburg, Germany, ⁶Radiology, Uniklinik Freiburg, freiburg, Germany

Para-Hydrogen Induced Polarization (PHIP) is a promising cost- and time-efficient technique for highly-sensitive metabolic MRI. We recently demonstrated PHIP with ¹³C-polarizations of 25% inside MRI systems at high field using spin-order transfer (SOT) sequences. Here, we show that SOT is extremely sensitive to limited proton-RF bandwidth available in MRI setups. This effect is crucial for hyperpolarization of metabolic agents like acetate and pyruvate; and for PHIP in human MRI setups, dedicated hardware may be required. Still, high-field PHIP is promising as the setup is inexpensive and simple and requires no transport of the agents to the MRI system is needed.

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