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Abstract #3806

Effect of Radical Concentration on the Hyperpolarization of Silicon Nanoparticles using Dynamic Nuclear Polarization

Catriona H.E. Rooney1, Jack J.J.J. Miller1,2,3, and Damian J. Tyler1,3
1Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, 2Department of Physics, University of Oxford, Oxford, United Kingdom, 3Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom

Silicon nanoparticles (SiNPs) retain enhanced polarization for several hours following hyperpolarization due to their long nuclear T1 relaxation time and are therefore attractive candidates for use as MRI contrast agents. However, “bare” SiNPs show low signal enhancement and require the addition of exogenous radicals to reach sufficient signal enhancements for MRI. Here, the addition of two radicals (Finland trityl and TEMPO) and the effect of their concentration on SiNP build-up and decay properties were investigated. Optimising SiNP polarization characteristics is necessary if their clinical translation as targeted hyperpolarized contrast agents is to be achieved.

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