Abstract #3836

Natural abundance deuterium MRS of the human calf and T1 measurements with a surface coil at 3 T

Robin A. Damion^1,2,3, Daniel J. Cocking^3,4, Brett Haywood^3,4, Matthew S. Brook^2,5,6, Paul L. Greenhaff^2,5,6, Philip J. Atherton^1,2,5, Dorothee P. Auer^1,2,3, and Richard Bowtell^2,3,4

¹School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, University of Nottingham, Nottingham, United Kingdom, ³Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ⁴School of Physics & Astronomy, University of Nottingham, Nottingham, United Kingdom, ⁵MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Nottingham, Nottingham, United Kingdom, ⁶School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Deuterium spectra of the human calf were obtained at natural abundance, at 3 T field strength. Two peaks with a chemical shift separation of 3.5 ppm were observed, corresponding to water and lipids, and their relaxation times T₁ and T₂* were measured using a transceive surface coil. Utilising the complex data to fit spectral lines, including independent phases for each peak, and fitting the complex inversion-recovery data enabled measurements of T₁ which could be frustrated by inversion-time-dependent phases caused by RF imperfections. The results indicate that such measurements in humans are possible despite the low natural abundance of ²H.

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