Abstract #3839

Healthy human aging and sex dimorphism in bone-muscle cross talk: a 1H MRS investigation in bone marrow and muscle of legs.

Silvia Capuani^1,2, Roberto Coccurello³, Riccardo De Feo⁴, Lorenzo Rossi⁵, Giulia Tuttobene⁵, Emanuele Agrimi⁵, Clelia Raso⁵, Federico Giove^2,4, and Umberto Tarantino⁶

¹Physics Dpt Sapienza, CNR ISC, Rome, Italy, ²Santa Lucia foundation, Rome, Italy, ³CNR ISC, Rome, Italy, ⁴Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Rome, Italy, ⁵Physics Dpt., Sapienza University, Rome, Italy, ⁶Tor Vergata University, PTV, Rome, Italy

Aim of this study was to identify relevant changes in the metabolic profile of bone-marrow and muscle during healthy aging in both men and women. Towards this goal, single-voxel MRS with STEAM at TE=6ms and T2 evaluation of each resonance was performed. Bone-marrow fatty-acids quantification show a clear sex dimorphism with normal aging while no significant differences were found in the muscle metabolites of female and male subjects. On the other hand, metabolite-T2 values were different in male and female resonances and significant T2 differences among 36+, 36-52 and 52+ group, finding higher T2 in older group were observed.

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