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Abstract #3839

Healthy human aging and sex dimorphism in bone-muscle cross talk: a 1H MRS investigation in bone marrow and muscle of legs.  

Silvia Capuani1,2, Roberto Coccurello3, Riccardo De Feo4, Lorenzo Rossi5, Giulia Tuttobene5, Emanuele Agrimi5, Clelia Raso5, Federico Giove2,4, and Umberto Tarantino6
1Physics Dpt Sapienza, CNR ISC, Rome, Italy, 2Santa Lucia foundation, Rome, Italy, 3CNR ISC, Rome, Italy, 4Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Rome, Italy, 5Physics Dpt., Sapienza University, Rome, Italy, 6Tor Vergata University, PTV, Rome, Italy

Aim of this study was to identify relevant changes in the metabolic profile of bone-marrow and muscle during healthy aging in both men and women. Towards this goal, single-voxel MRS with STEAM at TE=6ms and T2 evaluation of each resonance was performed. Bone-marrow fatty-acids quantification show a clear sex dimorphism with normal aging while no significant differences were found in the muscle metabolites of female and male subjects. On the other hand, metabolite-T2 values were different in male and female resonances and significant T2 differences among 36+, 36-52 and 52+ group, finding higher T2 in older group were observed.

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