Abstract #3838

Early Detection of Increased Marrow Adiposity with Age Using Z-Spectral MRI

Zimeng Cai^1,2, Quan Tao^1,2, Alessandro Scotti^3,4, Peiwei Yi^1,2, Yanqiu Feng^1,2, and Kejia Cai^3,4

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, Guangdong, China, ³The Department of Radiology and Bioengineering, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States, ⁴Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

To investigate the capability of Z-spectral magnetic resonance imaging (ZS-MRI) for the quantification of marrow adipose tissue (MAT) content in rat’s lumbar spine and to monitor the MAT changes due to age. First, three sets of water-oil mixed phantoms prepared with varying fat fractions (FF) were scanned and the quantification results were compared to ¹H-MRS and Dixon’s MRI methods. Then, ZS-MRI was used to longitudinally monitor the adiposity in the lumbar spine of healthy-young rats at 13, 17 and 21 weeks along with ¹H-MRS and Dixon’s MRI. The changes over time in FF of MAT were confirmed by histology staining.

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