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Abstract #3843

Fat Fraction Quantification in TSE based 2-point Dixon Acquisition: Application to Whole-body MRI

Sheng-Qing Lin1, Sebastian Fonseca1, Durga Udayakumar1, Neela Batthula1, Ivan E. Dimitrov2,3, Ivan Pedrosa1, and Ananth J. Madhuranthakam1
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Philips, Dallas, TX, United States

Mapping fat fraction (FF) has been proposed as a biomarker of treatment response in multiple myeloma. Whole-body imaging using 2-point Dixon methods offer efficient acquisitions but may suffer from less accurate FF quantification than multi-echo Dixon. Using our previously developed whole-body MR sequence with 2-point turbo spin-echo (TSE) Dixon, we generated accurate FF maps using with a fat masking algorithm. Results from a fat-water phantom and in vivo images show that 2-point TSE-Dixon with the fat masking algorithm performed comparably to multi-echo Dixon, facilitating accurate FF maps in whole-body MRI.

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