Mapping fat fraction (FF) has been proposed as a biomarker of treatment response in multiple myeloma. Whole-body imaging using 2-point Dixon methods offer efficient acquisitions but may suffer from less accurate FF quantification than multi-echo Dixon. Using our previously developed whole-body MR sequence with 2-point turbo spin-echo (TSE) Dixon, we generated accurate FF maps using with a fat masking algorithm. Results from a fat-water phantom and in vivo images show that 2-point TSE-Dixon with the fat masking algorithm performed comparably to multi-echo Dixon, facilitating accurate FF maps in whole-body MRI.
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