We explored the relationships between MRI lipid-imaging signatures and sterol regulatory element binding proteins (SREBPs) gene expression profiling of ten histologically proven glioma patients to elucidate the underlying inter- & intra-tumoural lipid distribution changes. The high expression of SREBPs was observed for grade II and III implied reprogramming of lipid metabolism. The identification of imaging biomarkers that can reflect changes in the genetic profiles of SREBP offers a new avenue for personalised medicine and the development of new therapeutic targets.
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