Abstract #3850

MRI lipid signatures and SREBPs gene expression profiling for characterisation of glioma: A preliminary study

Pohchoo Seow¹, K Rashid², Vairavan Narayanan ³, Azlina Ahmad-Annuar ⁴, Jeannie Wong², Li Kuo Tan², K Ibrahim⁴, and Norlisah Ramli²

¹Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, ²Department of Biomedical Imaging, University of Malaya, Kuala Lumpur, Malaysia, ³Department of Surgery, University of Malaya, Kuala Lumpur, Malaysia, ⁴Department of Biomedical Science, University of Malaya, Kuala Lumpur, Malaysia

We explored the relationships between MRI lipid-imaging signatures and sterol regulatory element binding proteins (SREBPs) gene expression profiling of ten histologically proven glioma patients to elucidate the underlying inter- & intra-tumoural lipid distribution changes. The high expression of SREBPs was observed for grade II and III implied reprogramming of lipid metabolism. The identification of imaging biomarkers that can reflect changes in the genetic profiles of SREBP offers a new avenue for personalised medicine and the development of new therapeutic targets.

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