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Abstract #3851

Comparing omega-3 content in adipose tissue of mice and rats fed a high omega-3 diet with MRS at 9.4T

Clara J. Fallone1, Anthony G. Tessier1,2, Catherine J. Field3, and Atiyah Yahya1,2
1Department of Oncology, University of Alberta, Edmonton, AB, Canada, 2Department of Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada, 3Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada

Omega-3 (ω-3) fat intake is important to disease and reflected in adipose tissue composition. Optimized PRESS (Point RESolved Spectroscopy) at 9.4T is used to quantify relative ω-3 fat content in adipose tissue of mice and rats fed a 16% ω-3 diet and in a control diet mouse. The actual ω-3 fat content in the mice was determined using gas chromatography and compared to that obtained using optimized MRS (R2 = 0.98). On average, the % ω-3 content measured with MRS in rat adipose tissue was approximately 39% higher than that in mouse.

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