Abstract #3852

Precision of STEAM-MRS for Multi-Parametric Quantification in Subjects with Liver Iron Overload at 1.5T and 3T

Gregory Simchick^1,2, Ruiyang Zhao^1,2, Gavin Hamilton³, Scott Reeder^1,2,4,5,6, and Diego Hernando^1,2,4

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, University of California-San Diego, San Diego, CA, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

The precision (repeatability and reproducibility) of quantitative stimulated echo acquisition mode (STEAM) MRS was evaluated in subjects with known or suspected liver iron overload at both 1.5T and 3T. The test-retest repeatability and reproducibility across acquisition modes (multi-TE vs multi-TE-TR) of STEAM-MRS multi-parametric quantification was evaluated using linear regression and Bland-Altman analyses. STEAM-MRS demonstrated high precision for several biomarkers, including R2_water and R2_fat, FWHM_water and FWHM_fat as surrogates for R2*, and PDFF, at both 1.5T and 3T. R1_water and R1_fat exhibited moderate repeatability. The precision of the water estimates (R1, R2, and FWHM) was relatively similar at both field strengths.

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