Abstract #3853

Fatty acid composition quantification in bone marrow at 7 T: method comparison and in vivo feasibility

Sevgi Emin¹, Jonas Svensson^1,2, Martin Englund³, and Pernilla Peterson^1,2

¹Medical Radiation Physics, Department of Translational Medicine, Lund University, Malmo, Sweden, ²Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden, ³Orthopaedics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

Chemical shift-encoded magnetic resonance imaging may be used to estimate the fatty acid composition (FAC) of bone marrow adipose tissue (BMAT), and the method may benefit from the improved spectral resolution at ultra-high field strength. In this work, the in vivo feasibility of FAC quantification in BMAT at 7 T was investigated, and simulations were used to determine the optimal image acquisition parameters and reconstruction model. The study showed that using a short inter-echo time, FAC quantification in BMAT was feasible and robust at 7 T, and that the noise performance might be improved using a constrained reconstruction model.

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