Abstract #3854

Breathing-induced B0 fluctuations bias proton density fat fraction and T2* mapping of brown adipose tissue in the supraclavicular fossa

Mingming Wu¹, Cora Held¹, Maximilian N. Diefenbach^1,2, Jakob Meineke³, Aashley S.D. Sardjoe Mishre^4,5, Kilian Weiss⁶, Hermien E. Kan⁵, Daniela Junker¹, Hans Hauner^7,8, and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, ²Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany, ³Philips Research Lab, Hamburg, Germany, ⁴Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, ⁶Philips Healthcare, Hamburg, Germany, ⁷Else Kröner Fresenius Center for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Munich, Germany, ⁸Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany

Proton density fat fraction and T2* mapping have been used to characterize fat tissue in the human supraclavicular fossa with the aim of detecting brown adipose tissue and its response to activation by changes of the two. However, chemical shift encoding-based water-fat separation in that region has been primarily performed in free-breathing mode. The present work reports on breathing-induced B₀ fluctuations in the human supraclavicular fossa, and the severe bias introduced on both PDFF and T2* quantification, as shown with simulated B₀ fluctuation effects. The effect of respiratory triggering on artefact reduction is investigated in a cohort of 13 volunteers.

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