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Abstract #3864

Magnetic resonance thermometry in activated interscapular brown adipose tissue of rats with various dose of norepinephrine

Chuanli Cheng1, Qian Wan1, Yangzi Qiao1, Changjun Tie1, Xin Liu1, Hairong Zheng1, and Chao Zou1
1Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences, Shenzhen, China

Magnetic Resonance thermometry (MRT) in activated brown adipose tissue (BAT) is able to measure the BAT function directly. A previous proposed fat-referenced 1H proton resonance frequency shift MRT method is adopted to compare the thermogenic capacity of rats injected with different dose of norepinephrine (NE). It is found that the rats with 2mg/kg and 1mg/kg NE injection had comparable maximum temperature rises after NE injection (7.1oC vs. 6.7oC), while temperature rises for rats with NE of 0.5mg/kg was significantly lower (3.8oC).

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