Abstract #3866

Robust Fat Suppression with Slice Selective Gradient Reversal (SSGR) in Amide Proton Transfer Imaging – Application to Non-Human Primate Brain

Hahnsung Kim^1,2, Lisa C. Krishnamurthy ^3,4, Jinsuh Kim⁵, and Phillip Zhe Sun^1,2

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ³Center for Visual and Neurocognitive Rehabilitation, Atlanta VA, Decatur, GA, United States, ⁴Department of Physics & Astronomy, Georgia State University, Atlanta, GA, United States, ⁵Department of Radiology, University of Alabama Birmingham, Birmingham, AL, United States

Single-shot EPI imaging has become a widely used acquisition method in amide proton transfer (APT) imaging due to its fast imaging readout. Because APT effects are relatively small, fat artifacts may significantly impact the asymmetry analysis. Recently, a slice selective gradient reversal (SSGR) method has been reported to effectively suppress fat signals. This work aims to introduce the SSGR method into spin-echo EPI APT imaging, which can be used for fat suppression in the non-human primate brain with substantial pericranial fat.

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