The measurement of temperature in fatty tissues remains a challenge, since the presence of fat protons modifies the phase difference and therefore introduces errors in the quantification from proton resonance frequency shift. By using Z-spectrum MRI, combined with a Jump-Return binomial pulse preparation, we create a sinusoidal variation of the signal as a function of the resonance frequency. The magnitude-based readout eliminates the risk of phase-related artifacts and allows to measure the subtle shifts of water resonance and therefore the temperature, even in fatty tissues. We tested the sequence in mice and cream phantom.
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