Abstract #3885

Longitudinal Study on Early Gestation T2*-based BOLD effect in Human Placenta

Ruiming Chen¹, Ante Zhu², Jitka Starekova³, Daniel Seiter¹, Kevin M. Johnson^1,3, Scott B. Reeder^1,3,4,5,6, Dinesh M. Shah⁷, Oliver Wieben^1,3, and Diego Hernando^1,3,4,8

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²GE Global Research, Niskayuna, NY, United States, ³Radiology, University of Wisconsin - Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁷Obstetrics and Gynecology, University of Wisconsin - Madison, Madison, WI, United States, ⁸Electrical and Computer Engineering, University of Wisconsin - Madison, Madison, WI, United States

Maternal obesity is associated with negative pregnancy outcomes, potentially due to insufficient placental flow and oxygen delivery. Blood oxygen level-dependent (BOLD) based T2* measurements are associated with oxygenation and have shown to provide assessment of placental function. Here, we report placental T2* values in a cohort of 70 obese and non-obese subjects with normal and adverse gestational outcomes. Results show variation of T2* histograms between normal subjects and subjects with pregnancy complications at both 14 and 20 weeks, whereas no significant median T2* value differences were observed in between non-obese and obese groups.

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