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Abstract #3886

Effects of Life-Long Western Diet Consumption on Fetal and Maternal Guinea Pig Body Composition at Mid-Gestation

Lindsay E Morris1, Flavien Delhaes2, Lanette Friesen Waldner1, Trevor Wade1, Lauren M Smith1, Mary-Ellen ET Empey1, Simran Sethi1, Timothy RH Regnault2,3,4, and Charles A McKenzie1,4
1Medical Biophysics, Western University, London, ON, Canada, 2Physiology and Pharmacology, Western University, London, ON, Canada, 3Obstetrics and Gynaecology, Western University, London, ON, Canada, 4Division of Maternal, Fetal and Newborn Health, Children's Health Research Institute, London, ON, Canada

Effects of a life-long high fat and high sugar diet (Western diet: WD) in ~38-day gestation guinea pigs. Pregnant life-long WD or control diet (CD) fed sows underwent T1-weighted and IDEAL water-fat images on a 3T MRI at mid gestation. Regions of interest were segmented around key volumes. The maternal liver volume and median fat fraction were significantly higher in WD relative to CD sows while measures of other fat depots were unaltered between diet groups. The fetal and placental volumes were not significantly different between the diet groups. This research expands our understanding of metabolically unhealthy pregnancies.

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