The prospective study aims to investigate the value of Synthetic MRI in evaluating the grading of bladder cancer (BCa). A total of 31 patients with pathologically confirmed BCa were enrolled. Regions of interest were manually drawn by two radiologists. Our results indicated that there were significant differences in the mean T2 and PD values between high- and low-grade BCa. The area under the ROC curve of the mean T2 and PD values were 0.761 and 0.880, respectively. Synthetic MRI is helpful for discriminating low- and high-grade BCa.