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Abstract #3893

The change of amide proton transfer (APT) signal intensity (SI) with age in testes of adults: A preliminary study

Wenhao Fu1, Yang Peng1, Guanglei Tang1, Weibo Chen2, Kan Deng3, Zhongping Zhang3, Yingjie Mei3, and Jian Guan1
1Department of Radiology´╝î the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, Guangzhou, China

Functional MRI, such as DWI and MTI, have been used to evaluate male infertility. Amide proton transfer (APT) is a novel MRI technique in the level of molecular imaging, which employs the chemical exchange of endogenous amide proton. This study investigated the relationship between amide proton transfer (APT) signal intensity (SI) changes with age in adults. According to the initial results of this research, we found that APT SI of testes was positively correlated age, which suggested that APT could be a potential biomarker for spermatogenic function.

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